PandemieGrippaleV1, 2020, Analysis, bibRecord, 000040

Digesting the crisis: autophagy and coronaviruses

Identifieur interne : 000040 ( 2020/Analysis ); précédent : 000039; suivant : 000041

Digesting the crisis: autophagy and coronaviruses

Auteurs : Didac Carmona-Gutierrez [Autriche] ; Maria Bauer [Autriche] ; Andreas Zimmermann [Autriche] ; Katharina Kainz [Autriche] ; Sebastian Hofer [Autriche] ; Guido Kroemer [France] ; Frank Madeo [Autriche]

Source :

Microbial Cell [ 2311-2638 ] ; 2020-05-04.

RBID : Hal:inserm-02612304

English descriptors

mix :
- COVID-19, MERS, SARS, SARS-CoV-2, coronavirus, immunity, inflammation, virophagy.

Abstract

Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the inhibition of excessive inflammatory reactions. In line with its central role in immunity, viruses have evolved mechanisms to interfere with or to evade the autophagic process, and in some cases, even to harness autophagy or constituents of the autophagic machinery for their replication. Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this piece, we provide a short overview of the evidence linking autophagy to coronaviruses and discuss whether such links may provide actionable targets for therapeutic interventions.

Url:

https://www.hal.inserm.fr/inserm-02612304

DOI: 10.15698/mic2020.05.715

Affiliations:

Autriche, France

Links toward previous steps (curation, corpus...)

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to stream Hal, to step Checkpoint: 000040
to stream Main, to step Merge: 000040
to stream Main, to step Curation: 000040
to stream Main, to step Exploration: 000040
to stream 2020, to step Extraction: 000040

Links to Exploration step

Hal:inserm-02612304

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the inhibition of excessive inflammatory reactions. In line with its central role in immunity, viruses have evolved mechanisms to interfere with or to evade the autophagic process, and in some cases, even to harness autophagy or constituents of the autophagic machinery for their replication. Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this piece, we provide a short overview of the evidence linking autophagy to coronaviruses and discuss whether such links may provide actionable targets for therapeutic interventions.</p>
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Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/2020/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000040 | SxmlIndent | more

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{{Explor lien
   |wiki=    Sante
   |area=    PandemieGrippaleV1
   |flux=    2020
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:inserm-02612304
   |texte=   Digesting the crisis: autophagy and coronaviruses
}}

This area was generated with Dilib version V0.6.34.
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Serveur d'exploration sur les pandémies grippales

Digesting the crisis: autophagy and coronaviruses

Digesting the crisis: autophagy and coronaviruses

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri